Ira Mellman: from endosomes to industry
نویسنده
چکیده
Disease-related research requires a different kind of teamwork, says Ira Mellman. He hopes to find that team at his new home at Genentech.
منابع مشابه
Actin dependence of polarized receptor recycling in MDCK cell endosomes
Mammalian epithelial cell plasma membrane domains are separated by junctional complexes supported by actin. The extent to which actin acts elsewhere to maintain cell polarity remains poorly understood. Using latrunculin B (Lat B) to depolymerize actin filaments, several basolateral plasma membrane proteins were found to lose their polarized distribution. This loss of polarity did not reflect la...
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Receptor recycling involves two endosome populations, peripheral early endosomes and perinuclear recycling endosomes. In polarized epithelial cells, either or both populations must be able to sort apical from basolateral proteins, returning each to its appropriate plasma membrane domain. However, neither the roles of early versus recycling endosomes in polarity nor their relationship to each ot...
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In mammalian cells, internalized receptors such as transferrin (Tfn) receptor are presumed to pass sequentially through early endosomes (EEs) and perinuclear recycling endosomes (REs) before returning to the plasma membrane. Whether passage through RE is obligatory, however, remains unclear. Kinetic analysis of endocytosis in CHO cells suggested that the majority of internalized Tfn bypassed RE...
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The system of tubules and vesicles that sorts and recycles molecules internalized from the plasma membrane is extremely complex. Newly endocytosed proteins are fi rst delivered to early endosomes, from where they can be quickly returned to the cell surface, or directed to late endosomes and lysosomes for degradation. Alternatively, endocytic cargoes can take a slower route, passing from early e...
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Endosomes are intermediates for a complex series of sorting and transport events that occur during receptor-mediated endocytosis. These involve the recognition of targeting determinants on the cytoplasmic domains of many membrane proteins as well as the formations of specific transport vesicles. Accordingly, endosome function is likely to be governed by the regulated assembly of cytoplasmic coa...
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ورودعنوان ژورنال:
- The Journal of Cell Biology
دوره 177 شماره
صفحات -
تاریخ انتشار 2007